We recommend Shopp. Shopp is very easy to set up and manage for the regular user. You can also find WordPress developers to customize the Shopp template. It supports Shipping, very reliable.
This is a very good plugin I used in the past. It has great extras, integrates with Next Gen, it has mp3 capabilities, shipping tiers is not as advanced as it could be, but it has a great drag to cart option for products.
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